Gene selection using a two-level hierarchical Bayesian model. Academic Article

abstract

• SUMMARY: The fundamental problem of gene selection via cDNA data is to identify which genes are differentially expressed across different kinds of tissue samples (e.g. normal and cancer). cDNA data contain large number of variables (genes) and usually the sample size is relatively small so the selection process can be unstable. Therefore, models which incorporate sparsity in terms of variables (genes) are desirable for this kind of problem. This paper proposes a two-level hierarchical Bayesian model for variable selection which assumes a prior that favors sparseness. We adopt a Markov chain Monte Carlo (MCMC) based computation technique to simulate the parameters from the posteriors. The method is applied to leukemia data from a previous study and a published dataset on breast cancer. SUPPLEMENTARY INFORMATION: http://stat.tamu.edu/people/faculty/bmallick.html.

authors

• Mallick, Bani

published proceedings

• Bioinformatics

author list (cited authors)

• Bae, K., & Mallick, B. K.

citation count

• 112

complete list of authors

• Bae, Kyounghwa||Mallick, Bani K

publication date

• December 2004

publisher

• Oxford University Press (OUP)  Publisher

published in

• Bioinformatics  Journal

keywords

• Algorithms
• Bayes Theorem
• Biomarkers, Tumor
• Gene Expression Profiling
• Genetic Testing
• Humans
• Leukemia
• Models, Genetic
• Models, Statistical
• Neoplasm Proteins
• Oligonucleotide Array Sequence Analysis
• Reproducibility Of Results
• Sensitivity And Specificity

PubMed Central ID

• 15256404

Digital Object Identifier (DOI)

• 10.1093/bioinformatics/bth419

start page

• 3423

end page

• 3430

volume

• 20

issue

• 18

URL

• http%3A%2F%2Fdx.doi.org%2F10.1093%2Fbioinformatics%2Fbth419