A membraneless high-throughput micro-separator
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We have developed a microfluidic platform capable of enabling rapid size-based separations of micron-scale species (particles, cells). The filtration architecture incorporates an embedded weir-like barrier separating two lanes with unequal depths, oriented parallel to the flow direction and extending along the entire centerline length of the microchannel. This design uniquely merges the high selectivity of a physical membrane barrier with the ability to operate at high flow rates (mL/min), making it possible to process large volumes with no clogging. We report new advancements that reveal the underlying physics, allowing rational design of devices based on this filtration approach.