Semiparametric inference in matched case-control studies with missing covariate data Academic Article

abstract

• We consider the problem of matched studies with a binary outcome that are analysed using conditional logistic regression, and for which data on some covariates are missing for some study participants. Methods for this problem involve either modelling the distribution of missing covariates or modelling the probability of data being missing. For this second approach, the previously proposed method did not make use of data for those persons with missing covariate data except in the model for the missingness. We propose a new class of estimators that use outcome and available covariate data for all study participants, and show that a particular member of this class always has better efficiency than the previously proposed estimator. We illustrate the efficiency gains that are possible with our approach using simulated data. 2002 Biometrika Trust.

authors

• Carroll, Raymond

published proceedings

• BIOMETRIKA

author list (cited authors)

• Rathouz, P. J., Satten, G. A., & Carroll, R. J.

citation count

• 18

complete list of authors

• Rathouz, PJ||Satten, GA||Carroll, RJ

publication date

• December 2002

publisher

• Oxford University Press (OUP)  Publisher

published in

• Biometrika  Journal

keywords

• Case-control Study
• Conditional Inference
• Estimating Equation
• Missing Data
• Projection
• Robustness
• Semiparametric
• Two-stage Study

Digital Object Identifier (DOI)

• 10.1093/biomet/89.4.905

start page

• 905

end page

• 916

volume

• 89

issue

• 4

URL

• http%3A%2F%2Fdx.doi.org%2F10.1093%2Fbiomet%2F89.4.905