Weighted logistic regression and robust analysis of diverse toxicology data Conference Paper uri icon


  • Simpson, Carroll, Zhou and Guth (1996) developed an ordinal response regression approach to meta-analysis of data from diverse toxicology studies, applying the methodology to a database of acute inhalation studies of tetrachloroethylene. We present an alternative analysis of the same data, with two major differences: (1) interval censored scores are assigned worst-case values, e.g., a score known to be in the interval [0, 1] is set equal to 1; and (2) the response is reduced to a binary response (adverse, nonadverse). We explore the stability of the analysis by varying a robustness parameter and graphing the curves traced out by the estimates and confidence intervals. Copyright 1996 by Marcel Dekker, Inc.

published proceedings


author list (cited authors)

  • Simpson, D. G., Carroll, R. J., Xie, M. G., & Guth, D. J.

citation count

  • 13

complete list of authors

  • Simpson, DG||Carroll, RJ||Xie, MG||Guth, DJ

publication date

  • January 1996