CRITICAL BOOLEAN NETWORKS REQUIRE MINIMAL INTERVENTION RATE
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abstract
A prime objective of modeling gene regulatory networks is the identification of potential targets for therapeutic intervention. To this end, it is crucial to understand the structure-dynamics relationships in biological networks. In this work, we investigate the relationship between the structure ofgene regulatory networks modeled as Boolean networks and the benefit-to-intervention-rate ratio of optimal intervention strategies derived for them.
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2009 IEEE International Workshop on Genomic Signal Processing and Statistics