Preparation of orthogonally-functionalized core Click cross-linked nanoparticles Academic Article uri icon


  • The preparation of well-defined core cross-linked polymeric nanoparticles is reported, utilizing multi-functional dendritic cross-linkers that allow for the effective stabilization of supramolecular polymer assemblies and the simultaneous introduction of reactive groups within the core domain. Amphiphilic diblock copolymers of poly(acrylic acid)-b-poly(styrene) (PAA-b-PS) that contained alkynyl functionality, partially incorporated throughout the hydrophobic PS block segment, were utilized as Click-readied precursors for the formation of polymer micelles. Divergently-grown dendrimers of the zero, first, second and third generations, having increasing numbers of azide terminating groups ((N3)2-[G-0], (N3)4-[G-1], (N3)8-[G-2], and (N3)16-[G-3], respectively), were investigated as cross-linkers via Click reactions with the polymer alkynyl groups to form covalent linkages throughout the micellar core domains, thus forming core cross-linked nanoparticles. All four generations of dendrimers were found to cross-link the micelle core effectively and afford robust nanostructures, whilst simultaneously introducing Click-readied functionalities throughout the hydrophobic domain, which are proposed to be readily available for further chemical modification. The Royal Society of Chemistry and the Centre National de la Recherche Scientifique.

published proceedings


altmetric score

  • 3

author list (cited authors)

  • O'Reilly, R. K., Joralemon, M. J., Hawker, C. J., & Wooley, K. L.

citation count

  • 82

complete list of authors

  • O‚ÄôReilly, Rachel K||Joralemon, Maisie J||Hawker, Craig J||Wooley, Karen L

publication date

  • January 2007