Strategies for optimized radiolabeling of nanoparticles for in vivo PET Imaging Academic Article uri icon

abstract

  • A new strategy has been developed for optimizing the process of radiolabeling of nanoparticles for in vivo positron emission tomography (PET) imaging. The new strategy involved a complete redesign of the nanoparticle system, utilizing macromolecular precursors that were preloaded with labeling sites and programmed for supramolecular assembly into discrete and functional nanoscale objects. A series shell-crosslinked nanoparticles (SCKs) were used in the study as the nanoscale framework for the attachment of macrocyclic chelators and labeling by copper (Cu) radionuclides. The new strategy can construct chelator-SCK conjugates, with high radiolabeling efficiencies leading to administration of nanoscale objects in small quantities for ultra-sensitive PET imaging. SCKs used in the study were comprised of polystyrene (PS) and polyacrylic acid (PAA) to optimize radiolabeling of nanoparticles for PET imaging.

published proceedings

  • ADVANCED MATERIALS

altmetric score

  • 6

author list (cited authors)

  • Sun, G., Xu, J., Hagooly, A., Rossin, R., Li, Z., Moore, D. A., ... Wooley, K. L.

citation count

  • 69

complete list of authors

  • Sun, Guorong||Xu, Jinqi||Hagooly, Aviv||Rossin, Raffaella||Li, Zicheng||Moore, Dennis A||Hawker, Craig J||Welch, Michael J||Wooley, Karen L

publication date

  • October 2007

publisher