Strategies for optimized radiolabeling of nanoparticles for in vivo PET Imaging
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abstract
A new strategy has been developed for optimizing the process of radiolabeling of nanoparticles for in vivo positron emission tomography (PET) imaging. The new strategy involved a complete redesign of the nanoparticle system, utilizing macromolecular precursors that were preloaded with labeling sites and programmed for supramolecular assembly into discrete and functional nanoscale objects. A series shell-crosslinked nanoparticles (SCKs) were used in the study as the nanoscale framework for the attachment of macrocyclic chelators and labeling by copper (Cu) radionuclides. The new strategy can construct chelator-SCK conjugates, with high radiolabeling efficiencies leading to administration of nanoscale objects in small quantities for ultra-sensitive PET imaging. SCKs used in the study were comprised of polystyrene (PS) and polyacrylic acid (PAA) to optimize radiolabeling of nanoparticles for PET imaging.