Labeling of Polymer Nanostructures for Medical Imaging: Importance of crosslinking extent, spacer length, and charge density. Academic Article uri icon


  • Radiolabeling studies were employed to investigate the influence of structure on the efficiency of surface functionalization for poly(acrylic acid)-coated shell crosslinked nanoparticles (SCKs) with two types of amine-terminated DOTA chelators. An intricate interplay between the chemical and physical properties of both the DOTA derivative and the SCK nanostructures was revealed, demonstrating the importance of structural control.

published proceedings

  • Macromolecules

altmetric score

  • 6

author list (cited authors)

  • Xu, J., Sun, G., Rossin, R., Hagooly, A., Li, Z., Fukukawa, K., ... Wooley, K. L.

citation count

  • 42

complete list of authors

  • Xu, Jinqi||Sun, Guorong||Rossin, Raffaella||Hagooly, Aviv||Li, Zicheng||Fukukawa, Ken-Ichi||Messmore, Benjamin W||Moore, Dennis A||Welch, Michael J||Hawker, Craig J||Wooley, Karen L

publication date

  • May 2007