Facile Synthesis of Clickable, Water-soluble and Degradable Polyphosphoesters. Academic Article uri icon


  • "Click" chemistry is a library of efficient and reliable reactions, which have been used to functionalize various classes of bio- and synthetic macromolecular systems for the incorporation of designed properties and functions. In this report, azide-alkyne Huisgen cycloaddition and thiol-yne reactions, two classical "click" chemistries, were employed to functionalize biodegradable, clickable polyphosphoester homopolymers and their water-soluble copolymers. A stable alkyne-functionalized phospholane monomer was synthesized, its organocatalyzed polymerization kinetics were evaluated, and the resulting (co)polymers were utilized to develop this facile method that provides the synthesis of clickable, water-soluble and degradable polyphosphoesters, which can be adapted for various applications.

published proceedings

  • ACS Macro Lett

author list (cited authors)

  • Zhang, S., Li, A., Zou, J., Lin, L. Y., & Wooley, K. L.

citation count

  • 133

complete list of authors

  • Zhang, Shiyi||Li, Ang||Zou, Jiong||Lin, Lily Yun||Wooley, Karen L

publication date

  • February 2012