Facile Synthesis of Clickable, Water-soluble and Degradable Polyphosphoesters. Academic Article

abstract

• "Click" chemistry is a library of efficient and reliable reactions, which have been used to functionalize various classes of bio- and synthetic macromolecular systems for the incorporation of designed properties and functions. In this report, azide-alkyne Huisgen cycloaddition and thiol-yne reactions, two classical "click" chemistries, were employed to functionalize biodegradable, clickable polyphosphoester homopolymers and their water-soluble copolymers. A stable alkyne-functionalized phospholane monomer was synthesized, its organocatalyzed polymerization kinetics were evaluated, and the resulting (co)polymers were utilized to develop this facile method that provides the synthesis of clickable, water-soluble and degradable polyphosphoesters, which can be adapted for various applications.

authors

• Wooley, Karen

published proceedings

• ACS Macro Lett

author list (cited authors)

• Zhang, S., Li, A., Zou, J., Lin, L. Y., & Wooley, K. L.

citation count

• 133

complete list of authors

• Zhang, Shiyi||Li, Ang||Zou, Jiong||Lin, Lily Yun||Wooley, Karen L

publication date

• February 2012

publisher

• American Chemical Society (ACS)  Publisher

published in

• ACS Macro Letters  Journal

keywords

• 0303 Macromolecular And Materials Chemistry
• 0305 Organic Chemistry

PubMed Central ID

• 22866244

Digital Object Identifier (DOI)

• 10.1021/mz200226m

start page

• 328

end page

• 333

volume

• 1

issue

• 2

URL

• http%3A%2F%2Fdx.doi.org%2F10.1021%2Fmz200226m