Formation of nanogel aggregates by an amphiphilic cholesteryl‐poly(amidoamine) dendrimer in aqueous media Academic Article uri icon

abstract

  • Synthesis process of nanogel aggregates by an hydroxyl poly(amidoamine) amphiphiles containing rigid lipids in which the degree of hydrophobicity was controlled so they remained water soluble, is discussed. The amphiphilic cholesteryl-poly(amidoamine) dendrimer (Ch-G5OH) was prepared by conjugating cholesteryl chloroformate with generation five hydroxyl-terminated poly(amidoamine) dendrimer in the presence of triethylamine (Et 3 N) in a particular ratio of dendrimer hydroxyl groups to cholesteryl chloroformate. The amphiphile was found easily dissolvable in water, producing a clear aqueous solution with stable foams on shaking. TEM image of the Ch-G5OH amphiphile cast from a sonicated aqueous solution showed a globular aggregation with an average diameter of 13 nm. The amphiphile aggregation was found to be dependent on exterior conditions such as solvent, dialysis, sonication, and temperature.

author list (cited authors)

  • Zhang, D., Hamilton, P. D., Kao, J. L., Venkataraman, S., Wooley, K. L., & Ravi, N.

citation count

  • 13

publication date

  • May 2007

publisher