Functionalized micellar assemblies prepared via block copolymers synthesized by living free radical polymerization upon peptide-loaded resins. Academic Article

abstract

• Hybrid peptidic-synthetic amphiphilic block copolymers, synthesized by living free radical polymerization (LFRP) on solid support, have been utilized as precursors for nanoscale materials possessing bio-available peptides. LFRP initiators, coupled to the peptide terminus upon the resin, facilitated the growth of homo- and block copolymers via nitroxide mediated radical polymerization (NMRP) or atom transfer radical polymerization (ATRP). Herein, the versatile solid-support synthesis of the antimicrobial peptide tritrpticin, coupling of living free radical polymerization initiators to the peptide-loaded resin, and the controlled radical polymerization of various monomers to yield amphiphilic diblock copolymers are described. Assembly of the peptidic-synthetic block copolymers into micelles and a preliminary assessment of their in vitro biological properties are detailed.

authors

• Wooley, Karen

published proceedings

• Biomacromolecules

altmetric score

• 6

author list (cited authors)

• Becker, M. L., Liu, J., & Wooley, K. L.

citation count

• 133

complete list of authors

• Becker, Matthew L||Liu, Jianquan||Wooley, Karen L

publication date

• January 2005

publisher

• American Chemical Society (ACS)  Publisher

published in

• Biomacromolecules  Journal

keywords

• Amino Acid Sequence
• Free Radicals
• Micelles
• Models, Molecular
• Molecular Structure
• Peptides
• Polymers
• Resins, Synthetic

Digital Object Identifier (DOI)

• 10.1021/bm049551y

start page

• 220

end page

• 228

volume

• 6

issue

• 1

URL

• http%3A%2F%2Fdx.doi.org%2F10.1021%2Fbm049551y