Orthogonally dual-clickable Janus nanoparticles via a cyclic templating strategy. Academic Article uri icon


  • Synthetic asymmetrical systems, Janus particles and patchy particles, are capable of undergoing hierarchical assembly processes that mimic those of Nature, to serve as switchable devices, optical probes, phase-transfer catalysts, and multifunctional drug carriers, each of which benefits from opposing surface patterns that behave differently. Production of nanometer-sized Janus particles that are equipped with efficient chemistries remains a challenge. A robust Janus-faced polymer nanoparticle framework that presents two orthogonally click-reactive surface chemistries has been generated by a recyclable strategy that involves reactive functional group transfer by templating against gold nanoparticle substrates. This anisotropic functionalization approach is compatible with a wide range of soft materials, providing Janus nanoparticles for the construction of dual-functionalized devices by accurately controlling chemical functionality at the nanoscopic level.

published proceedings

  • J Am Chem Soc

altmetric score

  • 1

author list (cited authors)

  • Zhang, S., Li, Z., Samarajeewa, S., Sun, G., Yang, C., & Wooley, K. L.

citation count

  • 52

complete list of authors

  • Zhang, Shiyi||Li, Zhou||Samarajeewa, Sandani||Sun, Guorong||Yang, Chao||Wooley, Karen L

publication date

  • July 2011