Shell crosslinked knedel-like nanoparticles for delivery of cisplatin: effects of crosslinking Academic Article uri icon

abstract

  • Polymeric micelles and shell crosslinked knedel-like (SCK) nanoparticles were loaded with up to 48% (w/w) cisplatin. These spherical cisplatin-loaded nanoparticles displayed sustained platinum release over 5 days in PBS, enhanced stability over free cisplatin in aqueous milieu, and significant antitumor activity in vitro against two cancer cell lines.

author list (cited authors)

  • Zhang, F., Elsabahy, M., Zhang, S., Lin, L. Y., Zou, J., & Wooley, K. L.

citation count

  • 34

publication date

  • March 2013