Shell crosslinked knedel-like nanoparticles for delivery of cisplatin: effects of crosslinking.

abstract

• Polymeric micelles and shell crosslinked knedel-like (SCK) nanoparticles were loaded with up to 48% (w/w) cisplatin. These spherical cisplatin-loaded nanoparticles displayed sustained platinum release over 5 days in PBS, enhanced stability over free cisplatin in aqueous milieu, and significant antitumor activity in vitro against two cancer cell lines.

authors

• Wooley, Karen

published proceedings

• Nanoscale

author list (cited authors)

• Zhang, F., Elsabahy, M., Zhang, S., Lin, L. Y., Zou, J., & Wooley, K. L.

citation count

• 39

complete list of authors

• Zhang, Fuwu||Elsabahy, Mahmoud||Zhang, Shiyi||Lin, Lily Yun||Zou, Jiong||Wooley, Karen L

publication date

• April 2013

publisher

• Royal Society of Chemistry (RSC)  Publisher

published in

• Nanoscale  Journal

keywords

• Animals
• Antineoplastic Agents
• Cells, Cultured
• Cisplatin
• Coated Materials, Biocompatible
• Cross-Linking Reagents
• Drug Carriers
• Drug Delivery Systems
• Drug Evaluation, Preclinical
• Drug Stability
• Humans
• Mice
• Micelles
• Models, Biological
• Nanoparticles
• Nanoshells
• Particle Size

PubMed Central ID

• 23474773

Digital Object Identifier (DOI)

• 10.1039/c3nr34320k

start page

• 3220

end page

• 3225

volume

• 5

issue

• 8

URL

• http%3A%2F%2Fdx.doi.org%2F10.1039%2Fc3nr34320k