Shell cross-linked nanoparticles designed to target angiogenic blood vessels via alpha(v)beta(3) receptor-ligand interactions

abstract

• The design, synthesis, and characterization of a novel polymeric nanostructured material bearing surface-attached integrin antagonists are demonstrated. The covalent coupling of a complex and biologically active small molecule to a well-defined nanostructured material combines the elegance of synthetic organic chemistry with the state-of-the-art polymer chemistry. This unique material offers potential in targeting to tumor neovasculature and delivery of diagnostic and therapeutic agents.

authors

• Wooley, Karen

published proceedings

• MACROMOLECULES

altmetric score

• 3

author list (cited authors)

• Pan, D. J., Turner, J. L., & Wooley, K. L.

citation count

• 54

complete list of authors

• Pan, DJ||Turner, JL||Wooley, KL

publication date

• September 2004

publisher

• American Chemical Society (ACS)  Publisher

published in

• MACROMOLECULES  Journal

keywords

• 34 Chemical Sciences
• 3403 Macromolecular And Materials Chemistry
• 40 Engineering
• 5 Development Of Treatments And Therapeutic Interventions
• 5.1 Pharmaceuticals
• Bioengineering
• Biotechnology
• Cancer
• Nanotechnology

Digital Object Identifier (DOI)

• 10.1021/ma048824e

start page

• 7109

end page

• 7115

volume

• 37

issue

• 19

URL

• http%3A%2F%2Fdx.doi.org%2F10.1021%2Fma048824e