REDOR Determination of the Composition of Shell Cross-Linked Amphiphilic Core−Shell Nanoparticles and the Partitioning of Sequestered Fluorinated Guests Academic Article uri icon

abstract

  • Rotational-echo double-resonance (REDOR) 13C{19F} and 15N{19F} NMR spectra have been obtained for guest-host complexes of 6-fluorotryptophan and 4-(trifluoromethyl)benzophenone with polymeric amphiphilic nanoparticles, consisting of a polystyrene core covalently attached to a poly(acrylic acid)-co-[15N]polyacrylamide shell. The REDOR spectra were used both to determine the composition of the nanoparticles and to find the locations of the fluorinated guests. Each guest resides near the core-shell interface of the nanoparticle, with the hydrophobic 4-(trifluoromethyl)benzophenone within the core and the amphiphilic 6-fluorotryptophan within the shell.

author list (cited authors)

  • Huang, H., Wooley, K. L., & Schaefer, J.

citation count

  • 26

publication date

  • January 2001