Influence of nanostructure morphology on host capacity and kinetics of guest release. Academic Article

abstract

• Morphology-dependent drug loading capacities and release kinetics are observed from pH-responsive diblock copolymer-based nano-objects, derived from the same block copolymer precursor. Shell-crosslinked, rod-shaped nanostructures exhibit a higher doxorubicin-loading capacity and rate of release than do their spherical counterparts. The extent of crosslinking and the type of crosslinker is also demonstrated to affect the rate of release. 2011 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

authors

• Wooley, Karen

published proceedings

• Small

altmetric score

• 3

author list (cited authors)

• Lee, N. S., Lin, L. Y., Neumann, W. L., Freskos, J. N., Karwa, A., Shieh, J. J., Dorshow, R. B., & Wooley, K. L.

citation count

• 24

complete list of authors

• Lee, Nam S||Lin, Lily Yun||Neumann, William L||Freskos, John N||Karwa, Amolkumar||Shieh, Jeng J||Dorshow, Richard B||Wooley, Karen L

publication date

• July 2011

publisher

• Wiley  Publisher

published in

• Small  Journal

keywords

• Cross-Linking Reagents
• Doxorubicin
• Drug Delivery Systems
• Hydrogen-Ion Concentration
• Kinetics
• Models, Chemical
• Nanostructures
• Solutions

PubMed Central ID

• 21678552

Digital Object Identifier (DOI)

• 10.1002/smll.201100567

start page

• 1998

end page

• 2003

volume

• 7

issue

• 14