Influence of nanostructure morphology on host capacity and kinetics of guest release.
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Morphology-dependent drug loading capacities and release kinetics are observed from pH-responsive diblock copolymer-based nano-objects, derived from the same block copolymer precursor. Shell-crosslinked, rod-shaped nanostructures exhibit a higher doxorubicin-loading capacity and rate of release than do their spherical counterparts. The extent of crosslinking and the type of crosslinker is also demonstrated to affect the rate of release. 2011 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.
author list (cited authors)
Lee, N. S., Lin, L. Y., Neumann, W. L., Freskos, J. N., Karwa, A., Shieh, J. J., Dorshow, R. B., & Wooley, K. L.
complete list of authors
Lee, Nam S||Lin, Lily Yun||Neumann, William L||Freskos, John N||Karwa, Amolkumar||Shieh, Jeng J||Dorshow, Richard B||Wooley, Karen L