Polyphosphoester-based cationic nanoparticles serendipitously release integral biologically-active components to serve as novel degradable inducible nitric oxide synthase inhibitors. Academic Article uri icon

abstract

  • A degradable polyphosphoester (PPE)-based cationic nanoparticle (cSCK), which is integrated constructed as a novel degradable drug device, demonstrates surprisingly efficient inhibition of inducible nitric oxide synthase (iNOS) transcription, and eventually inhibits nitric oxide (NO) over-production, without loading of any specific therapeutic drugs. This system may serve as a promising anti-inflammatory agent toward the treatment of acute lung injury.

published proceedings

  • Adv Mater

altmetric score

  • 3.2

author list (cited authors)

  • Shen, Y., Zhang, S., Zhang, F., Loftis, A., Pava-Sanders, A., Zou, J., ... Wooley, K. L.

citation count

  • 23

complete list of authors

  • Shen, Yuefei||Zhang, Shiyi||Zhang, Fuwu||Loftis, Alexander||Pavía-Sanders, Adriana||Zou, Jiong||Fan, Jingwei||Taylor, John-Stephen A||Wooley, Karen L

publication date

  • October 2013

publisher