Fundamental design aspects of amphiphilic shell-crosslinked nanoparticles for controlled release applications
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abstract
A unique method is developed for the controlled release of the hydrophobic polymer chains from the core of the shell crosslinked nanoparticles (SCKs) by selective cleavage of labile C-ON bonds present at the core-shell interface; this represents a methodology to probe the permeability of nanoscopic membranes and a means for applications in the controlled release of macromolecular species.