EXTENDED STEREOCONTROL IN SILYL GROUP-TRANSFER CYCLIZATIONS - CONTROL OF 4 CONTIGUOUS CHIRAL CENTERS Academic Article

abstract

• The potential for extended stereocontrol in silyl group-transfer cyclizations was explored in model studies which formed four contiguous chiral centers. The diastereofacial selectivity for the reaction of cyclized intermediates was outstanding for both fluoride and SnCl 2 -trityl chloride mediated reactions. Good simple diastereo-selectivity was observed in reactions initiated by prochiral silyl enolates.

authors

• Singleton, Daniel

published proceedings

• SYNTHESIS-STUTTGART

author list (cited authors)

• KLIMKO, P. G., & SINGLETON, D. A.

citation count

• 7

complete list of authors

• KLIMKO, PG||SINGLETON, DA

publication date

• January 1994

publisher

• Thieme  Publisher

published in

• Synthesis  Journal

keywords

• Cyclizations
• Group-transfer
• Intramolecular
• Michael Reactions
• Stereocontrol

Digital Object Identifier (DOI)

• 10.1055/s-1994-25618

start page

• 979

end page

• 982

volume

• 1994

issue

• 9

URL

• http%3A%2F%2Fdx.doi.org%2F10.1055%2Fs-1994-25618