Extended Stereocontrol in Silyl Group-Transfer Cyclizations: Control of Four Contiguous Chiral Centers Academic Article uri icon

abstract

  • The potential for extended stereocontrol in silyl group-transfer cyclizations was explored in model studies which formed four contiguous chiral centers. The diastereofacial selectivity for the reaction of cyclized intermediates was outstanding for both fluoride and SnCl 2 -trityl chloride mediated reactions. Good simple diastereo-selectivity was observed in reactions initiated by prochiral silyl enolates.

author list (cited authors)

  • Klimko*, P., & Singleton, D.

citation count

  • 5

publication date

  • January 1994