Extended Stereocontrol in Silyl Group-Transfer Cyclizations: Control of Four Contiguous Chiral Centers
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The potential for extended stereocontrol in silyl group-transfer cyclizations was explored in model studies which formed four contiguous chiral centers. The diastereofacial selectivity for the reaction of cyclized intermediates was outstanding for both fluoride and SnCl 2 -trityl chloride mediated reactions. Good simple diastereo-selectivity was observed in reactions initiated by prochiral silyl enolates.
author list (cited authors)
Klimko*, P., & Singleton, D.