Studies on the biosynthesis of phomoidride B (CP-263,114): evidence for a decarboxylative homodimerization pathway. Academic Article

abstract

• [reaction: see text]. Feeding experiments using a deuterium labeled C16 maleic anhydride and whole cell culture of ATCC 74256 led to the isolation of phomoidride B with deuterium incorporation at C(7) and C(19) as determined by 2H NMR and electrospray mass spectrometry. This result is in accord with a decarboxylative homodimerization of the C16 maleic anhydride as a key biosynthetic step leading to phomoidride B.

authors

• Russell, David

published proceedings

• Org Lett

author list (cited authors)

• Sulikowski, G. A., Agnelli, F., Spencer, P., Koomen, J. M., & Russell, D. H.

citation count

• 23

complete list of authors

• Sulikowski, Gary A||Agnelli, Fabio||Spencer, Paul||Koomen, John M||Russell, David H

publication date

• May 2002

publisher

• American Chemical Society (ACS)  Publisher

published in

• Organic Letters  Journal

keywords

• Decarboxylation
• Deuterium
• Magnetic Resonance Spectroscopy
• Maleic Anhydrides
• Penicillium
• Spectrometry, Mass, Electrospray Ionization

PubMed Central ID

• 11975600

Digital Object Identifier (DOI)

• 10.1021/ol025594k

start page

• 1447

end page

• 1450

volume

• 4

issue

• 9

URL

• http://dx.doi.org/10.1021/ol025594k