A novel surface-induced dissociation instrument for ion mobility-time-of-flight mass spectrometry Academic Article uri icon


  • A surface-normal surface-induced dissociation (SID) configuration specifically designed for coupling ion mobility spectrometry (IMS) and orthogonal time-of-flight (TOF) mass spectrometer is described. The instrument configuration and the effects of various operating parameters are critically evaluated using ion trajectory calculations (SIMION) and SID spectra of a series of model peptides. The utility of the instrument configuration for simultaneous acquisition of MS and MS-MS spectra in both data-dependent and non-data-dependent modes are also discussed. 2006 Elsevier B.V. All rights reserved.

published proceedings


author list (cited authors)

  • Sun, W., May, J. C., & Russell, D. H.

citation count

  • 26

complete list of authors

  • Sun, Wenjian||May, Jody C||Russell, David H

publication date

  • January 2007