Effects of matrix structure/acidity on ion formation in matrix-assisted laser desorption ionization mass spectrometry Academic Article uri icon


  • The involvement of ground and excited state proton transfer reactions in matrix-assisted laser desorption ionization (MALDI) of bradykinin and bovine insulin is examined using a series of p-substituted aniline compounds as matrices. Semiempirical calculations of ground and excited state acidity of the p-substituted aniline and anilinium ions are presented. A linear correlation between log (analyte [A + H]+ ion yield) and matrix acidity is obtained. The behavior of the seven p-substituted anilines is discussed in terms of the relationship between matrix compound structure, reactivity, and ability to act as a MALDI matrix.

published proceedings


author list (cited authors)

  • GimonKinsel, M., PrestonSchaffter, L. M., Kinsel, G. R., & Russell, D. H.

citation count

  • 38

complete list of authors

  • GimonKinsel, M||PrestonSchaffter, LM||Kinsel, GR||Russell, DH

publication date

  • March 1997