Effects of Matrix Structure/Acidity on Ion Formation in Matrix-Assisted Laser Desorption Ionization Mass Spectrometry
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The involvement of ground and excited state proton transfer reactions in matrix-assisted laser desorption ionization (MALDI) of bradykinin and bovine insulin is examined using a series of p-substituted aniline compounds as matrices. Semiempirical calculations of ground and excited state acidity of the p-substituted aniline and anilinium ions are presented. A linear correlation between log (analyte [A + H]+ ion yield) and matrix acidity is obtained. The behavior of the seven p-substituted anilines is discussed in terms of the relationship between matrix compound structure, reactivity, and ability to act as a MALDI matrix.
author list (cited authors)
Gimon-Kinsel, M., Preston-Schaffter, L. M., Kinsel, G. R., & Russell, D. H
complete list of authors
Gimon-Kinsel, Mary||Preston-Schaffter, Lisa M||Kinsel, Gary R||Russell, David H