A dual time-of-flight apparatus for an ion mobility-surface-induced dissociation-mass spectrometer for high-throughput peptide sequencing Academic Article uri icon


  • A novel ion mobility (IM)-surface-induced dissociation (SID)-mass spectrometer consisting of two independent time-of-flight (TOF) mass analyzers is described. The dual TOF instrument configuration facilitates high-throughput post-ionization separation and mass analysis of precursor and fragment ions, and the utility of 3D data acquisition is demonstrated for top-down proteomics by performing simultaneous acquisition of peptide mass maps and amino acid sequence determination. 2008 Elsevier B.V. All rights reserved.

published proceedings


author list (cited authors)

  • Sun, W., May, J. C., Gillig, K. J., & Russell, D. H.

citation count

  • 9

complete list of authors

  • Sun, Wenjian||May, Jody C||Gillig, Kent J||Russell, David H

publication date

  • October 2009