Models for taxol biosynthesis: SeO2 oxidation of taxadiene
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abstract
Together with the expected mono-oxidized taxa-4(20),11(12)-diene-5-ol (1) and taxa-4(5),11,20-diene-20-ol (2), a new taxane skeleton, 3,12-cyclotaxane (3), was obtained from chemical oxidation of taxadiene by selenium dioxide/t-butylhydroperoxide. Copyright Taylor & Francis Group, LLC.