Toward a stable apoptolidin derivative: identification of isoapoptolidin and selective deglycosylation of apoptolidin. Academic Article uri icon

abstract

  • [formula: see text] Isoapoptolidin was isolated from crude fermentation extracts of the apoptolidin-producing microorganism Nocardiopsis sp. Apoptolidin isomerizes to isoapoptolidin upon treatment with methanolic triethylamine to establish a 1.4:1 equilibrium mixture of isoapoptolidin and apoptolidin. Semisynthesis of a peracetylated and deglycosylated derivative of apoptolidin is also described.

author list (cited authors)

  • Pennington, J. D., Williams, H. J., Salomon, A. R., & Sulikowski, G. A

complete list of authors

  • Pennington, James D||Williams, Howard J||Salomon, Arthur R||Sulikowski, Gary A

publication date

  • January 1, 2002 11:11 AM