Toward a stable apoptolidin derivative: identification of isoapoptolidin and selective deglycosylation of apoptolidin. Academic Article

abstract

• [formula: see text] Isoapoptolidin was isolated from crude fermentation extracts of the apoptolidin-producing microorganism Nocardiopsis sp. Apoptolidin isomerizes to isoapoptolidin upon treatment with methanolic triethylamine to establish a 1.4:1 equilibrium mixture of isoapoptolidin and apoptolidin. Semisynthesis of a peracetylated and deglycosylated derivative of apoptolidin is also described.

authors

• Pennington, James

published proceedings

• Org Lett

altmetric score

• 6

author list (cited authors)

• Pennington, J. D., Williams, H. J., Salomon, A. R., & Sulikowski, G. A.

citation count

• 42

complete list of authors

• Pennington, James D||Williams, Howard J||Salomon, Arthur R||Sulikowski, Gary A

publication date

• October 2002

publisher

• American Chemical Society (ACS)  Publisher

published in

• Organic Letters  Journal

keywords

• Anti-Bacterial Agents
• Drug Stability
• Fermentation
• Glycosylation
• Inhibitory Concentration 50
• Isomerism
• Macrolides
• Mitochondrial Proton-translocating Atpases
• Molecular Conformation
• Structure-Activity Relationship

PubMed Central ID

• 12599468

Digital Object Identifier (DOI)

• 10.1021/ol026829v

start page

• 3823

end page

• 3825

volume

• 4

issue

• 22

URL

• http%3A%2F%2Fdx.doi.org%2F10.1021%2Fol026829v