Toward a stable apoptolidin derivative: identification of isoapoptolidin and selective deglycosylation of apoptolidin.
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[formula: see text] Isoapoptolidin was isolated from crude fermentation extracts of the apoptolidin-producing microorganism Nocardiopsis sp. Apoptolidin isomerizes to isoapoptolidin upon treatment with methanolic triethylamine to establish a 1.4:1 equilibrium mixture of isoapoptolidin and apoptolidin. Semisynthesis of a peracetylated and deglycosylated derivative of apoptolidin is also described.
author list (cited authors)
Pennington, J. D., Williams, H. J., Salomon, A. R., & Sulikowski, G. A.
complete list of authors
Pennington, James D||Williams, Howard J||Salomon, Arthur R||Sulikowski, Gary A