Identification of the First Riboflavin Catabolic Gene Cluster Isolated from Microbacterium maritypicum G10. Academic Article uri icon


  • Riboflavin is a common cofactor, and its biosynthetic pathway is well characterized. However, its catabolic pathway, despite intriguing hints in a few distinct organisms, has never been established. This article describes the isolation of a Microbacterium maritypicum riboflavin catabolic strain, and the cloning of the riboflavin catabolic genes. RcaA, RcaB, RcaD, and RcaE were overexpressed and biochemically characterized as riboflavin kinase, riboflavin reductase, ribokinase, and riboflavin hydrolase, respectively. Based on these activities, a pathway for riboflavin catabolism is proposed.

published proceedings

  • J Biol Chem

altmetric score

  • 2.5

author list (cited authors)

  • Xu, H., Chakrabarty, Y., Philmus, B., Mehta, A. P., Bhandari, D., Hohmann, H., & Begley, T. P.

citation count

  • 10

complete list of authors

  • Xu, Hui||Chakrabarty, Yindrila||Philmus, Benjamin||Mehta, Angad P||Bhandari, Dhananjay||Hohmann, Hans-Peter||Begley, Tadhg P

publication date

  • November 2016