Inhibitors of pantothenate kinase: novel antibiotics for staphylococcal infections.
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abstract
Pantothenate kinase (CoaA) catalyzes the first step of the coenzyme A biosynthetic pathway. Here we report the identification of the Staphylococcus aureus coaA gene and characterization of the enzyme. We have also identified a series of low-molecular-weight compounds which are effective inhibitors of S. aureus CoaA.
Choudhry, A. E., Mandichak, T. L., Broskey, J. P., Egolf, R. W., Kinsland, C., Begley, T. P., ... Ratnam, K.
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Choudhry, Anthony E||Mandichak, Tracy L||Broskey, John P||Egolf, Richard W||Kinsland, Cynthia||Begley, Tadhg P||Seefeld, Mark A||Ku, Thomas W||Brown, James R||Zalacain, Magdalena||Ratnam, Kapila