Inhibitors of pantothenate kinase: novel antibiotics for staphylococcal infections.
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Pantothenate kinase (CoaA) catalyzes the first step of the coenzyme A biosynthetic pathway. Here we report the identification of the Staphylococcus aureus coaA gene and characterization of the enzyme. We have also identified a series of low-molecular-weight compounds which are effective inhibitors of S. aureus CoaA.
Antimicrob Agents Chemother
author list (cited authors)
Choudhry, A. E., Mandichak, T. L., Broskey, J. P., Egolf, R. W., Kinsland, C., Begley, T. P., ... Ratnam, K.
complete list of authors
Choudhry, Anthony E||Mandichak, Tracy L||Broskey, John P||Egolf, Richard W||Kinsland, Cynthia||Begley, Tadhg P||Seefeld, Mark A||Ku, Thomas W||Brown, James R||Zalacain, Magdalena||Ratnam, Kapila