Inhibitors of Pantothenate Kinase: Novel Antibiotics for Staphylococcal Infections Academic Article uri icon

abstract

  • Pantothenate kinase (CoaA) catalyzes the first step of the coenzyme A biosynthetic pathway. Here we report the identification of the Staphylococcus aureus coaA gene and characterization of the enzyme. We have also identified a series of low-molecular-weight compounds which are effective inhibitors of S. aureus CoaA.

altmetric score

  • 6

author list (cited authors)

  • Choudhry, A. E., Mandichak, T. L., Broskey, J. P., Egolf, R. W., Kinsland, C., Begley, T. P., ... Ratnam, K.

citation count

  • 68

publication date

  • June 2003