Inhibitors of pantothenate kinase: novel antibiotics for staphylococcal infections. Academic Article uri icon


  • Pantothenate kinase (CoaA) catalyzes the first step of the coenzyme A biosynthetic pathway. Here we report the identification of the Staphylococcus aureus coaA gene and characterization of the enzyme. We have also identified a series of low-molecular-weight compounds which are effective inhibitors of S. aureus CoaA.

published proceedings

  • Antimicrob Agents Chemother

altmetric score

  • 6

author list (cited authors)

  • Choudhry, A. E., Mandichak, T. L., Broskey, J. P., Egolf, R. W., Kinsland, C., Begley, T. P., ... Ratnam, K.

citation count

  • 73

complete list of authors

  • Choudhry, Anthony E||Mandichak, Tracy L||Broskey, John P||Egolf, Richard W||Kinsland, Cynthia||Begley, Tadhg P||Seefeld, Mark A||Ku, Thomas W||Brown, James R||Zalacain, Magdalena||Ratnam, Kapila

publication date

  • June 2003