Oxidative cascades: A facile biosynthetic strategy for the assembly of complex molecules Academic Article uri icon


  • Electron-rich aromatic compounds undergo a facile tandem reaction sequence involving an iterative two-electron oxidation/aromatization. This review will describe the application of this motif to the synthesis of dimethylbenzimidazole, pyoverdine, actinomycin, cystodytin, pyrroloquinoline quinone, and the cataract pigment.

author list (cited authors)

  • Dorrestein, P., & Begley, T. P.

citation count

  • 15

publication date

  • June 2005