Formation of the dimethylbenzimidazole ligand of coenzyme B(12) under physiological conditions by a facile oxidative cascade.
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Dimethylbezimidazole, the axial ligand of vitamin B(12), is synthesized from riboflavin by a two-electron oxidation, a retro-aldol condensation, and a second two-electron oxidation. This oxidative cascade readily takes place nonenzymatically under physiological conditions. [reaction: see text]
author list (cited authors)
Maggio-Hall, L. A., Dorrestein, P. C., Escalante-Semerena, J. C., & Begley, T. P.
complete list of authors
Maggio-Hall, Lori A||Dorrestein, Pieter C||Escalante-Semerena, Jorge C||Begley, Tadhg P