Formation of the dimethylbenzimidazole ligand of coenzyme B(12) under physiological conditions by a facile oxidative cascade. Academic Article uri icon


  • Dimethylbezimidazole, the axial ligand of vitamin B(12), is synthesized from riboflavin by a two-electron oxidation, a retro-aldol condensation, and a second two-electron oxidation. This oxidative cascade readily takes place nonenzymatically under physiological conditions. [reaction: see text]

published proceedings

  • Org Lett

author list (cited authors)

  • Maggio-Hall, L. A., Dorrestein, P. C., Escalante-Semerena, J. C., & Begley, T. P.

citation count

  • 27

complete list of authors

  • Maggio-Hall, Lori A||Dorrestein, Pieter C||Escalante-Semerena, Jorge C||Begley, Tadhg P

publication date

  • June 2003