DNA-protein cross-linking: model systems for pyrimidine-aromatic amino acid cross-linking.
- Additional Document Info
- View All
[reaction: see text] We have synthesized simple model systems to explore the possibility of photo-cross-linking between the pyrimidine bases and the side chains of the aromatic amino acids. Thymine/phenylalanine and thymine/tyrosine models gave cross-links, and thymine/tryptophan models gave complex mixtures; the cytosine/phenylalanine model was unreactive. The quantum yields for the model cross-linking reactions were 18-46 times smaller than those for thymine dimer formation. Biphotonic excitation contributes little to the yield of these reactions.
author list (cited authors)
Sun, G., Fecko, C. J., Nicewonger, R. B., Webb, W. W., & Begley, T. P.
complete list of authors
Sun, Guangxing||Fecko, Christopher J||Nicewonger, Robert B||Webb, Watt W||Begley, Tadhg P