DNA-protein cross-linking: model systems for pyrimidine-aromatic amino acid cross-linking. Academic Article

abstract

• [reaction: see text] We have synthesized simple model systems to explore the possibility of photo-cross-linking between the pyrimidine bases and the side chains of the aromatic amino acids. Thymine/phenylalanine and thymine/tyrosine models gave cross-links, and thymine/tryptophan models gave complex mixtures; the cytosine/phenylalanine model was unreactive. The quantum yields for the model cross-linking reactions were 18-46 times smaller than those for thymine dimer formation. Biphotonic excitation contributes little to the yield of these reactions.

authors

• Begley, Tadhg

published proceedings

• Org Lett

author list (cited authors)

• Sun, G., Fecko, C. J., Nicewonger, R. B., Webb, W. W., & Begley, T. P.

citation count

• 32

complete list of authors

• Sun, Guangxing||Fecko, Christopher J||Nicewonger, Robert B||Webb, Watt W||Begley, Tadhg P

publication date

• February 2006

publisher

• American Chemical Society (ACS)  Publisher

published in

• Organic Letters  Journal

keywords

• Amino Acids, Aromatic
• Cross-Linking Reagents
• DNA
• Models, Biological
• Proteins
• Pyrimidines

PubMed Central ID

• 16468741

Digital Object Identifier (DOI)

• 10.1021/ol052876m

start page

• 681

end page

• 683

volume

• 8

issue

• 4

URL

• http%3A%2F%2Fdx.doi.org%2F10.1021%2Fol052876m