DNA-protein cross-linking: model systems for pyrimidine-aromatic amino acid cross-linking. Academic Article uri icon


  • [reaction: see text] We have synthesized simple model systems to explore the possibility of photo-cross-linking between the pyrimidine bases and the side chains of the aromatic amino acids. Thymine/phenylalanine and thymine/tyrosine models gave cross-links, and thymine/tryptophan models gave complex mixtures; the cytosine/phenylalanine model was unreactive. The quantum yields for the model cross-linking reactions were 18-46 times smaller than those for thymine dimer formation. Biphotonic excitation contributes little to the yield of these reactions.

published proceedings

  • Org Lett

author list (cited authors)

  • Sun, G., Fecko, C. J., Nicewonger, R. B., Webb, W. W., & Begley, T. P.

citation count

  • 32

complete list of authors

  • Sun, Guangxing||Fecko, Christopher J||Nicewonger, Robert B||Webb, Watt W||Begley, Tadhg P

publication date

  • February 2006