Radical S-adenosylmethionine (SAM) enzymes in cofactor biosynthesis: a treasure trove of complex organic radical rearrangement reactions. Academic Article uri icon

abstract

  • In this minireview, we describe the radical S-adenosylmethionine enzymes involved in the biosynthesis of thiamin, menaquinone, molybdopterin, coenzyme F420, and heme. Our focus is on the remarkably complex organic rearrangements involved, many of which have no precedent in organic or biological chemistry.

published proceedings

  • J Biol Chem

altmetric score

  • 3

author list (cited authors)

  • Mehta, A. P., Abdelwahed, S. H., Mahanta, N., Fedoseyenko, D., Philmus, B., Cooper, L. E., ... Begley, T. P.

citation count

  • 57

complete list of authors

  • Mehta, Angad P||Abdelwahed, Sameh H||Mahanta, Nilkamal||Fedoseyenko, Dmytro||Philmus, Benjamin||Cooper, Lisa E||Liu, Yiquan||Jhulki, Isita||Ealick, Steven E||Begley, Tadhg P

publication date

  • February 2015