Identification of the product of toxoflavin lyase: degradation via a Baeyer-Villiger oxidation. Academic Article uri icon


  • Toxoflavin (an azapteridine) is degraded to a single product by toxoflavin lyase (TflA) in a reaction dependent on reductant, Mn(II), and oxygen. The isolated product was fully characterized by NMR and MS and was identified as a triazine in which the pyrimidine ring was oxidatively degraded. A mechanism for toxoflavin degradation based on the identification of the enzymatic product and the recently determined crystal structure of toxoflavin lyase is proposed.

published proceedings

  • J Am Chem Soc

author list (cited authors)

  • Philmus, B., Abdelwahed, S., Williams, H. J., Fenwick, M. K., Ealick, S. E., & Begley, T. P.

citation count

  • 11

complete list of authors

  • Philmus, Benjamin||Abdelwahed, Sameh||Williams, Howard J||Fenwick, Michael K||Ealick, Steven E||Begley, Tadhg P

publication date

  • March 2012