Identification of the product of toxoflavin lyase: degradation via a Baeyer-Villiger oxidation. Academic Article

abstract

• Toxoflavin (an azapteridine) is degraded to a single product by toxoflavin lyase (TflA) in a reaction dependent on reductant, Mn(II), and oxygen. The isolated product was fully characterized by NMR and MS and was identified as a triazine in which the pyrimidine ring was oxidatively degraded. A mechanism for toxoflavin degradation based on the identification of the enzymatic product and the recently determined crystal structure of toxoflavin lyase is proposed.

authors

• Begley, Tadhg

published proceedings

• J Am Chem Soc

author list (cited authors)

• Philmus, B., Abdelwahed, S., Williams, H. J., Fenwick, M. K., Ealick, S. E., & Begley, T. P.

citation count

• 11

complete list of authors

• Philmus, Benjamin||Abdelwahed, Sameh||Williams, Howard J||Fenwick, Michael K||Ealick, Steven E||Begley, Tadhg P

publication date

• March 2012

publisher

• American Chemical Society (ACS)  Publisher

published in

• Journal of the American Chemical Society  Journal

keywords

• Lyases
• Manganese
• Models, Molecular
• Molecular Structure
• Oxidation-Reduction
• Oxygen
• Pyrimidinones
• Triazines

PubMed Central ID

• 22304755

Digital Object Identifier (DOI)

• 10.1021/ja211759n

start page

• 5326

end page

• 5330

volume

• 134

issue

• 11