Thiamin biosynthesis: still yielding fascinating biological chemistry. Academic Article

abstract

• The present paper describes the biosynthesis of the thiamin thiazole in Bacillus subtilis and Saccharomyces cerevisiae. The two pathways are quite different: in B. subtilis, the thiazole is formed by an oxidative condensation of glycine, deoxy-D-xylulose 5-phosphate and a protein thiocarboxylate, whereas, in S. cerevisiae, the thiazole is assembled from glycine, NAD and Cys205 of the thiazole synthase.

authors

• Begley, Tadhg

published proceedings

• Biochem Soc Trans

altmetric score

• 1

author list (cited authors)

• Begley, T. P., Ealick, S. E., & McLafferty, F. W.

citation count

• 35

complete list of authors

• Begley, Tadhg P||Ealick, Steven E||McLafferty, Fred W

publication date

• January 2012

publisher

• Portland Press  Publisher

published in

• Biochemical Society Transactions  Journal

keywords

• Bacillus Subtilis
• Biosynthetic Pathways
• Isomerases
• Saccharomyces Cerevisiae
• Sulfides
• Thiamine

Digital Object Identifier (DOI)

• 10.1042/BST20120084

start page

• 555

end page

• 560

volume

• 40

issue

• 3