Thiamin biosynthesis: still yielding fascinating biological chemistry. Academic Article uri icon


  • The present paper describes the biosynthesis of the thiamin thiazole in Bacillus subtilis and Saccharomyces cerevisiae. The two pathways are quite different: in B. subtilis, the thiazole is formed by an oxidative condensation of glycine, deoxy-D-xylulose 5-phosphate and a protein thiocarboxylate, whereas, in S. cerevisiae, the thiazole is assembled from glycine, NAD and Cys205 of the thiazole synthase.

published proceedings

  • Biochem Soc Trans

altmetric score

  • 1

author list (cited authors)

  • Begley, T. P., Ealick, S. E., & McLafferty, F. W.

citation count

  • 36

complete list of authors

  • Begley, Tadhg P||Ealick, Steven E||McLafferty, Fred W

publication date

  • June 2012