The mechanism of action of bacimethrin, a naturally occurring thiamin antimetabolite. Academic Article uri icon

abstract

  • The mechanism of bacimethrin (2) toxicity has been determined. This compound is converted to 2'-methoxy-thiamin pyrophosphate (10) by the thiamin biosynthetic enzymes. Of the seven thiamin pyrophosphate utilizing enzymes in Escherichia coli, 2'-methoxy-thiamin pyrophosphate inhibits alpha-ketoglutarate dehydrogenase, transketolase, and deoxy-D-xylulose-5-phosphate synthase. Bacimethrin does not cause repression of the genes coding for the thiamin biosynthetic enzymes.

published proceedings

  • Bioorg Med Chem Lett

author list (cited authors)

  • Reddick, J. J., Saha, S., Lee, J., Melnick, J. S., Perkins, J., & Begley, T. P.

citation count

  • 60

complete list of authors

  • Reddick, JJ||Saha, S||Lee, J||Melnick, JS||Perkins, J||Begley, TP

publication date

  • September 2001