The mechanism of action of bacimethrin, a naturally occurring thiamin antimetabolite.
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The mechanism of bacimethrin (2) toxicity has been determined. This compound is converted to 2'-methoxy-thiamin pyrophosphate (10) by the thiamin biosynthetic enzymes. Of the seven thiamin pyrophosphate utilizing enzymes in Escherichia coli, 2'-methoxy-thiamin pyrophosphate inhibits alpha-ketoglutarate dehydrogenase, transketolase, and deoxy-D-xylulose-5-phosphate synthase. Bacimethrin does not cause repression of the genes coding for the thiamin biosynthetic enzymes.
author list (cited authors)
Reddick, J. J., Saha, S., Lee, J., Melnick, J. S., Perkins, J., & Begley, T. P.
complete list of authors
Reddick, JJ||Saha, S||Lee, J||Melnick, JS||Perkins, J||Begley, TP