Tryptophan catabolism: identification and characterization of a new degradative pathway. Academic Article uri icon


  • A new tryptophan catabolic pathway is characterized from Burkholderia cepacia J2315. In this pathway, tryptophan is converted to 2-amino-3-carboxymuconate semialdehyde, which is enzymatically degraded to pyruvate and acetate via the intermediates 2-aminomuconate and 4-oxalocrotonate. This pathway differs from the proposed mammalian pathway which converts 2-aminomuconate to 2-ketoadipate and, ultimately, glutaryl-coenzyme A.

published proceedings

  • J Bacteriol

altmetric score

  • 3

author list (cited authors)

  • Colabroy, K. L., & Begley, T. P.

citation count

  • 54

complete list of authors

  • Colabroy, Keri L||Begley, Tadhg P

publication date

  • November 2005