Mechanistic studies on the repair of a novel DNA photolesion: the spore photoproduct.

abstract

• [formula: see text] UV irradiation of spores results in the formation of the spore photoproduct. This novel DNA photolesion is repaired in the germinating spore in a reaction catalyzed by the spore photoproduct lyase. Model studies, using a simple bispyrimidine, suggest that this repair reaction proceeds by hydrogen abstraction from C6 of the spore photoproduct followed by beta-scission of the bond linking the two pyrimidines and back hydrogen atom transfer.

authors

• Begley, Tadhg

published proceedings

• Org Lett

altmetric score

• 3

author list (cited authors)

• Mehl, R. A., & Begley, T. P.

citation count

• 54

complete list of authors

• Mehl, RA||Begley, TP

publication date

• October 1999

publisher

• American Chemical Society (ACS)  Publisher

published in

• Organic Letters  Journal

keywords

• Catalysis
• DNA Damage
• DNA Repair
• DNA, Bacterial
• Deoxyribodipyrimidine Photo-lyase
• Proteins
• Spores, Bacterial

PubMed Central ID

• 10825958

Digital Object Identifier (DOI)

• 10.1021/ol9908676

start page

• 1065

end page

• 1066

volume

• 1

issue

• 7

URL

• http%3A%2F%2Fdx.doi.org%2F10.1021%2Fol9908676