Mechanistic studies on the repair of a novel DNA photolesion: the spore photoproduct. Academic Article uri icon


  • [formula: see text] UV irradiation of spores results in the formation of the spore photoproduct. This novel DNA photolesion is repaired in the germinating spore in a reaction catalyzed by the spore photoproduct lyase. Model studies, using a simple bispyrimidine, suggest that this repair reaction proceeds by hydrogen abstraction from C6 of the spore photoproduct followed by beta-scission of the bond linking the two pyrimidines and back hydrogen atom transfer.

published proceedings

  • Org Lett

altmetric score

  • 3

author list (cited authors)

  • Mehl, R. A., & Begley, T. P.

citation count

  • 54

complete list of authors

  • Mehl, RA||Begley, TP

publication date

  • October 1999