Biosynthesis of a thiamin antivitamin in Clostridium botulinum. Academic Article

abstract

• Bacimethrin-derived 2'-methoxythiamin pyrophosphate inhibits microbial growth by disrupting metabolic pathways dependent on thiamin-utilizing enzymes. This study describes the discovery of the bacimethrin biosynthetic gene cluster of Clostridium botulinum A ATCC 19397 and in vitro reconstitution of bacimethrin biosynthesis from cytidine 5'-monophosphate.

authors

• Begley, Tadhg

published proceedings

• Biochemistry

author list (cited authors)

• Cooper, L. E., O'Leary, S. E., & Begley, T. P.

citation count

• 10

complete list of authors

• Cooper, Lisa E||O'Leary, Seán E||Begley, Tadhg P

publication date

• April 2014

publisher

• American Chemical Society (ACS)  Publisher

published in

• Biochemistry  Journal

keywords

• Clostridium Botulinum
• Multigene Family
• Thiamine

PubMed Central ID

• 24654570

Digital Object Identifier (DOI)

• 10.1021/bi500281a

start page

• 2215

end page

• 2217

volume

• 53

issue

• 14

URL

• http%3A%2F%2Fdx.doi.org%2F10.1021%2Fbi500281a