Biosynthesis of a thiamin antivitamin in Clostridium botulinum.
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Bacimethrin-derived 2'-methoxythiamin pyrophosphate inhibits microbial growth by disrupting metabolic pathways dependent on thiamin-utilizing enzymes. This study describes the discovery of the bacimethrin biosynthetic gene cluster of Clostridium botulinum A ATCC 19397 and in vitro reconstitution of bacimethrin biosynthesis from cytidine 5'-monophosphate.
author list (cited authors)
Cooper, L. E., O'Leary, S. E., & Begley, T. P.
complete list of authors
Cooper, Lisa E||O'Leary, Seán E||Begley, Tadhg P