A NOVEL HETEROBIMETALLIC ASYMMETRIC HYDROGENATION CATALYST BASED UPON A CHIRAL RHENIUM TEMPLATE CONTAINING 2 PHOSPHIDO SUBSTITUENTS
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The Rhodiumrhenium complex 1 can be regarded as prototype of a new generation of hydrogenation catalysts. A salientcharacteristic is the coupling of an Rh1 centerknown to exhibit catalytic activity in hydrogenationswith a bis(diphenylphosphido) ligand, which contains a pseudotetrahedrally coordinated stereogenic Re atom in the skeletal framework. For example, acetamidoacrylic acid is hydrogenated in presence of 1 (0.4 mol% in THF) with 1 atm H2 at room temperature to (R)Nacetylalanine with 98% ee (yield: 82%). (Figure Presented.) Copyright 1987 by VCH Verlagsgesellschaft mbH, Germany