A Novel Heterobimetallic Asymmetric Hydrogenation Catalyst Based Upon a Chiral Rhenium Template Containing Two Phosphido Substituents Academic Article uri icon

abstract

  • The Rhodium–rhenium complex 1 can be regarded as prototype of a new generation of hydrogenation catalysts. A salient‐characteristic is the coupling of an Rh1 center—known to exhibit catalytic activity in hydrogenations—with a bis(diphenylphosphido) ligand, which contains a pseudo‐tetrahedrally coordinated stereogenic Re atom in the skeletal framework. For example, α‐acetamidoacrylic acid is hydrogenated in presence of 1 (0.4 mol‐% in THF) with 1 atm H2 at room temperature to (R)‐N‐acetylalanine with 98% ee (yield: 82%). (Figure Presented.) Copyright © 1987 by VCH Verlagsgesellschaft mbH, Germany

author list (cited authors)

  • Zwick, B. D., Arif, A. M., Patton, A. T., & Gladysz, J. A.

citation count

  • 33

publication date

  • September 1987

publisher