Evidence for binding of dirhodium bis-acetate units to adjacent GG and AA sites on single-stranded DNA Academic Article uri icon


  • Dirhodium tetraacetate is an antitumor active compound that is known to inhibit cellular DNA synthesis, but relatively little is known about its interactions with nucleic acids. A combination of matrix-assisted laser desorption/ionization mass spectrometry (MALDI MS) and enzymatic digestion experiments has established that the dirhodium bis-acetate unit forms an adduct with AA and GG sites in short DNA strands. The MALDI MS detection of the dirhodium/DNA adduct was aided by the addition of spermine, but no special sample treatment was required to obtain high quality mass spectra of the corresponding cisplatin-modified DNA strands.

published proceedings


author list (cited authors)

  • Asara, J. M., Hess, J. S., Lozada, E., Dunbar, K. R., & Allison, J.

citation count

  • 79

complete list of authors

  • Asara, JM||Hess, JS||Lozada, E||Dunbar, KR||Allison, J

publication date

  • December 2000