Synthetic support of de novo design: sterically bulky [FeFe]-hydrogenase models. Academic Article uri icon


  • (Figure Presented) A twisted mimic: Upon oxidation of [(-SCH 2C(CH3)2CH2S-){Fe I(CO)2PMe3}2], rearrangement yields the mixed-valent FeIFeII cation in a square-pyramid/ inverted square-pyramid geometry with a semibridging CO ligand, closely mimicking the [FeFe] hydrogenase enzyme active site. According to de novo design principles, the steric effect of bridgehead bulk in the S-S bridging ligand stabilizes this structure in the absence of the protein matrix. 2008 Wiley-VCH Verlag GmbH & Co. KGaA.

published proceedings

  • Angew Chem Int Ed Engl

author list (cited authors)

  • Singleton, M. L., Bhuvanesh, N., Reibenspies, J. H., & Darensbourg, M. Y.

citation count

  • 138

complete list of authors

  • Singleton, Michael L||Bhuvanesh, Nattamai||Reibenspies, Joseph H||Darensbourg, Marcetta Y

publication date

  • October 2008