Enhanced antiopiate activity in peptidomimetics of FMRFamide containing Z-2,3-methanomethionine. Academic Article

abstract

• FMRFa is a molluscan peptide that has shown antiopiate activity in a number of mammalian test systems. The current study determined the antiopiate potency of FMRFa and two conformationally constrained peptidomimetics of FMRFa containing stereoisomers of Z-2,3-methanomethionine. Morphine abstinence signs were observed after varying doses (0.25-25.0 micrograms) of these substances were injected into the third ventricle of morphine-dependent rats. Although both peptidomimetics were far more potent than FMRFa itself, they bound with lower affinity than FMRFa to rat spinal cord receptors for the mammalian FMRFa-like peptide, NPFF.

authors

• Burgess, Kevin

published proceedings

• Peptides

author list (cited authors)

• Malin, D. H., Payza, K., Lake, J. R., Corriere, L. S., Benson, T. M., Smith, D. A., ... Burgess, K.

citation count

• 27

complete list of authors

• Malin, DH||Payza, K||Lake, JR||Corriere, LS||Benson, TM||Smith, DA||Kelley, RS||Ho, KK||Burgess, K

publication date

• January 1993

publisher

• Elsevier  Publisher

published in

• Peptides  Journal

keywords

• Amino Acid Sequence
• Animals
• Endorphins
• Fmrfamide
• In Vitro Techniques
• Male
• Methionine
• Molecular Sequence Data
• Molecular Structure
• Morphine Dependence
• Neuropeptides
• Oligopeptides
• Rats
• Rats, Sprague-Dawley
• Receptors, Neurotransmitter

PubMed Central ID

• 8382812

Digital Object Identifier (DOI)

• 10.1016/0196-9781(93)90009-6

start page

• 47

end page

• 51

volume

• 14

issue

• 1

URL

• http%3A%2F%2Fdx.doi.org%2F10.1016%2F0196-9781%2893%2990009-6