Early manifestations of dementing illness: treatment with glycosaminoglycan polysulfate. Academic Article uri icon


  • 1. In a multicenter, placebo-controlled, double-blind clinical trial in 156 elderly patients with psychopathologic symptoms, glycosaminoglycan polysulfate was found to be a therapeutically effective agent in the treatment of the earliest manifestations of a dementing process. 2. Treatment with glycosaminoglycan polysulfate in the daily dosage of 600 LRU, administered on the basis of a divided dosage schedule for 24 weeks, was significantly superior to an inactive placebo on several outcome measures including the SCAG Total and factor scores (i.e., Cognitive Dysfunction, Withdrawal, Agitation/Irritability and Depression), the NOWLIS Total and Fatiguability factor scores, the MMSE, the HAM-D Total and Vegetative Symptoms factor score and the CGI Severity of Illness and Global Improvement. 3. The drug was well tolerated; vital signs and laboratory measures did not show clinically significant changes within the experimental period.

published proceedings

  • Prog Neuropsychopharmacol Biol Psychiatry

altmetric score

  • 3

author list (cited authors)

  • Ban, T. A., Morey, L. C., Fjetland, O. K., Rengo, F., Ferrara, N., Agnetti, V., ... Perego, M. A

citation count

  • 6

complete list of authors

  • Ban, TA||Morey, LC||Fjetland, OK||Rengo, F||Ferrara, N||Agnetti, V||D'Onofrio, M||Facchini, G||Anzivino, F||Perego, MA

publication date

  • September 1992