Post-training reversible inactivation of hippocampus reveals interference between memory systems. Academic Article uri icon


  • A post-training reversible lesion technique was used to examine the effects of neural inactivation of the dorsal hippocampus on place and response learning. Male Long-Evans rats trained in one of two versions of a water plus-maze task received post-training intra-hippocampal infusions of the local anesthetic drug bupivacaine (0.75% solution, 0.5 microl), or saline. Post-training intra-hippocampal infusions of bupivacaine attenuated acquisition of the place task and enhanced acquisition of the response task. Delayed (2-h) post-training infusions of bupivacaine did not affect retention in either task. The findings demonstrate (1) enhanced learning after reversible hippocampal lesions that is independent of treatment influences on non-mnemonic factors, and (2) inactivation of the dorsal hippocampus during the post-training memory consolidation period is sufficient to enhance response learning.

published proceedings

  • Hippocampus

author list (cited authors)

  • Schroeder, J. P., Wingard, J. C., & Packard, M. G.

citation count

  • 135

complete list of authors

  • Schroeder, Jason P||Wingard, Jeffrey C||Packard, Mark G

publication date

  • May 2002