Increased postural sway predicts negative symptom progression in youth at ultrahigh risk for psychosis. Academic Article

abstract

• Impaired ability to maintain an upright posture may reflect impairment in the cerebellum, a critical structure for the fluid coordination of neural information, thought to be disrupted in psychosis. The current study utilized an instrumental measure of posture in individuals at ultrahigh risk (UHR) for psychosis (n=43) and healthy controls (n=44). Positive and negative symptoms were assessed twice over 12months. Results showed that increased postural sway in the UHR group predicted changes in negative symptoms. This study provides an important prospective view on the relationship between cerebellar-sensitive behavior and integral symptoms, which until now has received limited biomarker research.

authors

• Bernard, Jessica
• Orr, Joseph

published proceedings

• Schizophr Res

altmetric score

• 5.35

author list (cited authors)

• Dean, D. J., Kent, J. S., Bernard, J. A., Orr, J. M., Gupta, T., Pelletier-Baldelli, A., Carol, E. E., & Mittal, V. A.

citation count

• 44

complete list of authors

• Dean, Derek J||Kent, Jerillyn S||Bernard, Jessica A||Orr, Joseph M||Gupta, Tina||Pelletier-Baldelli, Andrea||Carol, Emily E||Mittal, Vijay A

publication date

• March 2015

publisher

• Elsevier  Publisher

published in

• Schizophrenia Research  Journal

keywords

• Adolescent
• Cerebellum
• Cognitive Dysmetria
• Disease Progression
• Female
• Follow-Up Studies
• Humans
• Interview, Psychological
• Linear Models
• Male
• Postural Balance
• Postural Sway
• Posture
• Prodromal Symptoms
• Prognosis
• Psychiatric Status Rating Scales
• Psychosis
• Psychotic Disorders
• Risk
• Severity Of Illness Index
• Ultrahigh Risk
• Young Adult

PubMed Central ID

• 25601361

Digital Object Identifier (DOI)

• 10.1016/j.schres.2014.12.039

start page

• 86

end page

• 89

volume

• 162

issue

• 1-3

URL

• http%3A%2F%2Fdx.doi.org%2F10.1016%2Fj.schres.2014.12.039