Rewarding affective properties of intra-nucleus accumbens injections of testosterone. Academic Article

abstract

• On alternating days, adult male Long-Evans rats implanted with bilateral cannulas in the nucleus accumbens received intracerebral injections of testosterone in a water-soluble cyclodextrin inclusion complex (0.125, 0.25, or 0.5 microg/0.5 microl saline) or saline immediately prior to being confined for 30 min to 1 of 2 compartments of a place-preference apparatus. All rats received 8 days of pairings (4 hormone and 4 saline). On Day 9 the rats were given a 20-min test session during which they had access to all compartments of the apparatus. No hormone was injected prior to the test session. On the test day, rats spent significantly more time in the compartment previously paired with bilateral intra-accumbens injections of testosterone (0.25 and 0.5 microg/0.5 microl saline) than in the compartment previously paired with saline injections. The findings indicate that intra-accumbens injections of testosterone are sufficient to produce reward.

authors

• Alexander, Gerianne
• Packard, Mark

published proceedings

• Behav Neurosci

author list (cited authors)

• Packard, M. G., Cornell, A. H., & Alexander, G. M.

citation count

• 127

complete list of authors

• Packard, MG||Cornell, AH||Alexander, GM

publication date

• February 1997

publisher

• American Psychological Association (APA)  Publisher

published in

• BEHAVIORAL NEUROSCIENCE  Journal

keywords

• Affect
• Animals
• Association Learning
• Brain Mapping
• Conditioning, Psychological
• Dose-Response Relationship, Drug
• Male
• Motivation
• Nucleus Accumbens
• Rats
• Testosterone

PubMed Central ID

• 9109641

Digital Object Identifier (DOI)

• 10.1037//0735-7044.111.1.219

start page

• 219

end page

• 224

volume

• 111

issue

• 1

URL

• http%3A%2F%2Fdx.doi.org%2F10.1037%2F0735-7044.111.1.219