Affective properties of intra-medial preoptic area injections of testosterone in male rats. Academic Article

abstract

• On alternating days, adult male Long-Evans rats implanted with unilateral cannulae in the medial preoptic area (MPOA) received intracerebral injections of testosterone (0.05, 0.1 or 0.2 microg/0.5 microl), or saline immediately prior to confinement for 30 min to one of two compartments of a place preference apparatus. All rats received 8 days of pairings (4 hormone and 4 saline). On day 9, the rats were given a hormone-free 20-min test session during which they had access to all compartments of the apparatus. Intra-MPOA injections of testosterone (0.1 microg) produced a conditioned place preference, while injections of a higher dose (0.2 microg) produced a conditioned place aversion. The rewarding effects of intra-MPOA testosterone may in part mediate the facilatory effects of testosterone on motivational aspects of sexual behavior.

authors

• Alexander, Gerianne
• Packard, Mark

published proceedings

• Neurosci Lett

author list (cited authors)

• King, B. E., Packard, M. G., & Alexander, G. M.

citation count

• 35

complete list of authors

• King, BE||Packard, MG||Alexander, GM

publication date

• January 1999

publisher

• Elsevier  Publisher

published in

• NEUROSCIENCE LETTERS  Journal

keywords

• Affect
• Animals
• Male
• Microinjections
• Preoptic Area
• Rats
• Rats, Long-Evans
• Reward
• Testosterone

PubMed Central ID

• 10454154

Digital Object Identifier (DOI)

• 10.1016/s0304-3940(99)00440-1

start page

• 149

end page

• 152

volume

• 269

issue

• 3

URL

• http%3A%2F%2Fdx.doi.org%2F10.1016%2Fs0304-3940%2899%2900440-1