High-speed photoacoustic microscopy of mouse cortical microhemodynamics.

abstract

• We applied high-speed photoacoustic microscopy (PAM) for both cortical microenvironment studies and dynamic brain studies, with micrometer-level optical resolution and a millisecond-level cross-sectional imaging speed over a millimeter-level field of view. We monitored blood flow redistribution in mini-stroke mouse models and cerebral autoregulation induced by a vasoactive agent. Our results collectively suggest that high-speed PAM is a promising tool for understanding dynamic neurophysiological phenomena, complementing conventional imaging modalities.

authors

• Zou, Jun

published proceedings

• J Biophotonics

altmetric score

• 11.5

author list (cited authors)

• Lin, L. i., Yao, J., Zhang, R., Chen, C., Huang, C., Li, Y., ... Wang, L. V.

citation count

• 24

complete list of authors

• Lin, Li||Yao, Junjie||Zhang, Ruiying||Chen, Chun-Cheng||Huang, Chih-Hsien||Li, Yang||Wang, Lidai||Chapman, William||Zou, Jun||Wang, Lihong V

publication date

• June 2017

publisher

• Wiley  Publisher

published in

• Journal of Biophotonics  Journal

keywords

• Animals
• Blood Flow Redistribution
• Brain
• Cerebral Autoregulation
• Cortical Hemodynamics
• Female
• Mems Scanning Mirror
• Mice
• Microhemorrhage
• Microscopy
• Photoacoustic Microscopy
• Photoacoustic Techniques
• Spectrum Analysis

PubMed Central ID

• 28009098

Digital Object Identifier (DOI)

• 10.1002/jbio.201600236

start page

• 792

end page

• 798

volume

• 10

issue

• 6-7

URL

• http%3A%2F%2Fdx.doi.org%2F10.1002%2Fjbio.201600236