High-speed photoacoustic microscopy of mouse cortical microhemodynamics. Academic Article uri icon


  • We applied high-speed photoacoustic microscopy (PAM) for both cortical microenvironment studies and dynamic brain studies, with micrometer-level optical resolution and a millisecond-level cross-sectional imaging speed over a millimeter-level field of view. We monitored blood flow redistribution in mini-stroke mouse models and cerebral autoregulation induced by a vasoactive agent. Our results collectively suggest that high-speed PAM is a promising tool for understanding dynamic neurophysiological phenomena, complementing conventional imaging modalities.

altmetric score

  • 11.5

author list (cited authors)

  • Lin, L. i., Yao, J., Zhang, R., Chen, C., Huang, C., Li, Y., ... Wang, L. V.

citation count

  • 18

complete list of authors

  • Lin, Li||Yao, Junjie||Zhang, Ruiying||Chen, Chun-Cheng||Huang, Chih-Hsien||Li, Yang||Wang, Lidai||Chapman, William||Zou, Jun||Wang, Lihong V