DNA affinity to biological membranes is enhanced due to complexation with hydrophobized polycation.
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The interaction of negatively charged liquid phosphatidylcholine/cardiolipin liposomes with water-soluble negatively charged DNA/cetylpyridinium bromide and DNA/poly(N-alkyl-4-vinylpyridinium bromide) complexes was studied. It is shown that the DNA/cetylpyridinium bromide complex while interacting with the liposomes is destroyed, so that the cetylpyridinium cation is incorporated into the liposomal membrane and DNA remains in the solution. The DNA/poly-(N-ethyl-4-vinylpyridinium bromide) complex does not interact at all with the liposomes. On the contrary, the complex of DNA with the poly(vinylpyridinium) cation carrying a small amount of N-cetyl groups is adsorbed on the membrane as a whole. The data obtained indicate that complexation of DNA with hydrophobized polycations can be used for enhancing DNA affinity to biological membranes.
author list (cited authors)
Yaroslavov, A. A., Sukhishvili, S. A., Obolsky, O. L., Yaroslavova, E. G., Kabanov, A. V., & Kabanov, V. A
complete list of authors
Yaroslavov, AA||Sukhishvili, SA||Obolsky, OL||Yaroslavova, EG||Kabanov, AV||Kabanov, VA