DNA affinity to biological membranes is enhanced due to complexation with hydrophobized polycation. Academic Article

abstract

• The interaction of negatively charged liquid phosphatidylcholine/cardiolipin liposomes with water-soluble negatively charged DNA/cetylpyridinium bromide and DNA/poly(N-alkyl-4-vinylpyridinium bromide) complexes was studied. It is shown that the DNA/cetylpyridinium bromide complex while interacting with the liposomes is destroyed, so that the cetylpyridinium cation is incorporated into the liposomal membrane and DNA remains in the solution. The DNA/poly-(N-ethyl-4-vinylpyridinium bromide) complex does not interact at all with the liposomes. On the contrary, the complex of DNA with the poly(vinylpyridinium) cation carrying a small amount of N-cetyl groups is adsorbed on the membrane as a whole. The data obtained indicate that complexation of DNA with hydrophobized polycations can be used for enhancing DNA affinity to biological membranes.

authors

• Sukhishvili, Svetlana

published proceedings

• FEBS Lett

altmetric score

• 6

author list (cited authors)

• Yaroslavov, A. A., Sukhishvili, S. A., Obolsky, O. L., Yaroslavova, E. G., Kabanov, A. V., & Kabanov, V. A

citation count

• 26

complete list of authors

• Yaroslavov, AA||Sukhishvili, SA||Obolsky, OL||Yaroslavova, EG||Kabanov, AV||Kabanov, VA

publication date

• April 1996

publisher

• Wiley  Publisher

published in

• FEBS Letters  Journal

keywords

• Cardiolipins
• Cations
• Cetylpyridinium
• Chemical Phenomena
• Chemistry, Physical
• DNA
• Liposomes
• Membrane Lipids
• Phosphatidylcholines
• Polyvinyls

PubMed Central ID

• 8612818

Digital Object Identifier (DOI)

• 10.1016/0014-5793(96)00281-5

start page

• 177

end page

• 180

volume

• 384

issue

• 2

URL

• http%3A%2F%2Fdx.doi.org%2F10.1016%2F0014-5793%2896%2900281-5