Chemical analysis of Karenia papilionacea. Academic Article

abstract

• One of the most widely studied organisms responsible for Harmful Algal Blooms (HABs) is the marine dinoflagellate Karenia brevis. This organism produces neurotoxic compounds known as brevetoxins. A related dinoflagellate, Karenia papilionacea, has been reported to occasionally co-bloom with K. brevis but has received little attention as a possible toxin producing species. Therefore, our aim was to investigate the toxin profile for K.papilionacea. A toxic fraction was identified using a cell based cytotoxicity assay and the toxin was isolated and identified as the ladder frame polyether brevetoxin-2 (PbTx-2) using mass spectrometry (MS) and nuclear magnetic resonance (NMR). Toxin production in K.papilionacea increased in response to hypoosmotic stress, as previously observed in K.brevis.

authors

• Campbell, Lisa

published proceedings

• Toxicon

author list (cited authors)

• Fowler, N., Tomas, C., Baden, D., Campbell, L., & Bourdelais, A.

citation count

• 19

complete list of authors

• Fowler, Nicholas||Tomas, Carmelo||Baden, Daniel||Campbell, Lisa||Bourdelais, Andrea

publication date

• January 2015

publisher

• Elsevier  Publisher

published in

• Toxicon  Journal

keywords

• Brevetoxin
• Dinoflagellida
• HAB
• Harmful Algal Bloom
• Karenia Brevis
• Karenia Papilionacea
• Magnetic Resonance Spectroscopy
• Marine Toxins
• Osmotic Pressure
• Osmotic Stress
• Oxocins
• Stress, Physiological
• Toxin Isolation

PubMed Central ID

• 25981346

Digital Object Identifier (DOI)

• 10.1016/j.toxicon.2015.05.007

start page

• 85

end page

• 91

volume

• 101

URL

• http%3A%2F%2Fdx.doi.org%2F10.1016%2Fj.toxicon.2015.05.007