Acids and quinine as dietary adulterants
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Female rats were maintained for 30 days on diets containing various concentrations by weight of quinine or of acetic, butyric, or citric acid. Concentration-dependent undereating and weight loss was induced with dry ground-chow diets containing citric acid (5.25, 10.5, 15.75 or 21%) or with wet-mash diets containing either acetic, butyric (1.75, 3.5, 5.25 or 7.0% for both acids) or citric acid (7.5, 15.0, 22.5 or 30.0%). Wet-mash diets containing quinine (0.08, 0.12, 0.16 or 0.20%) induced initial undereating and weight loss with considerable adaptation (weight gain) after the tenth day. Only butyric acid (all concentrations) induced rumenal ulceration. Both acetic and citric acid appear to be useful alternatives to quinine as dietary adulterants. © 1979.
author list (cited authors)
Peters, R. H., Wellman, P. J., Gunion, M. W., & Luttmers, L. L.